Peptides for libido: what the evidence says
PT-141 is an approved medicine for low sexual desire in premenopausal women, sold as Vyleesi. Melanotan II, a related peptide, is sold online for tanning and libido.
This page has not yet been reviewed by a credentialed medical professional. It is educational and is not medical advice.
PT-141 is FDA-approved after phase 3 trials, but only for premenopausal women with low sexual desire; evidence in men is thinner. Melanotan II is unapproved.
What people use, ranked by evidence
Strongest evidence first. The numbers come live from PubMed and ClinicalTrials.gov.
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PT-141
FDA-approvedWhat people use it for: Low sexual desire. Approved for premenopausal women; also used off-label by men.
What the evidence says: FDA-approved under the brand name Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women based on two pivotal Phase 3 trials (RECONNECT).
14 randomized trials 10 registered trials Approved for: Hypoactive sexual desire disorder in premenopausal women Sport: Check listPT-141 profile → -
Melanotan II
Human trialsWhat people use it for: Tanning and libido. Sold online; regulators have warned against it.
What the evidence says: Small human studies exist, but it is unapproved and carries recognized safety concerns.
4 randomized trials 1 registered trial Not approved as a medicine Sport: Check listMelanotan II profile →
Common questions
Is PT-141 approved?
Yes, as bremelanotide (Vyleesi), for hypoactive sexual desire disorder in premenopausal women.
Does PT-141 work for men?
It is used off-label by men, but the evidence in men is much thinner than the phase 3 trials in women.
Other goals
"What people use it for" describes common claims, not recommendations. Educational only, not medical advice.