Longevity & mitochondria

Epitalon

Name: Epitalon: uses, evidence and safety
Creator: Cited Peptides Editorial

Also called Epithalon

Longevity, sleep and "telomere" claims.

By Cited Peptides Editorial Updated 2026-10-10 Medical review pending

This page has not yet been reviewed by a credentialed medical professional. It is educational and is not medical advice.

Epitalon: key facts

Evidence level Animal studies only
Approved as a medicineNo
Randomized trials on PubMed0
Papers on PubMed115
Trials testing it (ClinicalTrials.gov)None found
In tested sportCheck the current WADA Prohibited List

In one sentence: Epitalon is not an approved medicine. Its strongest evidence is animal studies, with 0 randomized trials on PubMed that mention it.

What the evidence says

Evidence comes largely from animal studies and small reports from one research group.

Key studies

Reviews Summaries of other studies.

Review2002 Peptides and Ageing Neuro Endocrinol Lett PMID 12374906 → Review2026 Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions J Am Acad Orthop Surg Glob Res Rev PMID 41490200 → Review2025 Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties Int J Mol Sci PMID 40141333 → Review2026 Therapeutic peptides in gerontology: mechanisms and applications for healthy aging Front Aging PMID 42021992 →

Other notable papers The most relevant other papers on PubMed.

Research Support, Non-U.S. Gov't2025 Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity Biogerontology PMID 40908429 → Research Support, Non-U.S. Gov't2022 Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro Aging (Albany NY) PMID 35413689 → Research Support, Non-U.S. Gov't2025 The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy Stem Cell Rev Rep PMID 40493162 → 2002 [Aging of the pineal gland] Adv Gerontol PMID 12096440 →

See its full evidence profile and newest papers →

Clinical trials

No registered trials list Epitalon as a treatment.

That usually means it hasn't been properly tested in people.

Search all trials live →

Where it fits

GoalPeptides for longevity ComparisonMOTS-c vs Epitalon

Common questions

Is Epitalon approved?

No. Epitalon is not an approved medicine in the US or Canada.

Has Epitalon been tested in people?

No randomized trials of Epitalon are listed on PubMed. Evidence comes largely from animal studies and small reports from one research group.

Is Epitalon allowed in sport?

Check the current WADA Prohibited List; unapproved substances can be banned under its catch-all category.

This is a short, data-driven profile. Study and trial lists come from PubMed and ClinicalTrials.gov and are refreshed periodically. "What people use it for" describes common claims, not recommendations. Educational only, not medical advice.