"GHK-Cu copper peptide reverses wrinkles."
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Rating:
Lab studies show it can boost collagen production in cells. Clinical proof in skincare is thin.
The evidence
Cell work from 1988 showed increased collagen synthesis in fibroblast cultures. A 2025 review of topical GHK concluded cell data support an anti-wrinkle role but found a surprising absence of clinical studies and open questions about how much reaches the skin.
Sources
- Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. (FEBS Lett, 1988)
- Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective. (Bioimpacts, 2025)