Ipamorelin vs Sermorelin
Which has more real evidence behind it? This compares how well each has been tested, not which one works better.
This page has not yet been reviewed by a credentialed medical professional. It is educational and is not medical advice.
Sermorelin has the stronger evidence: FDA-approved, compared with human trials for Ipamorelin.
The research, side by side
Counts come from PubMed and ClinicalTrials.gov searches and can include studies that only mention a peptide. Bars use a log scale.
| Ipamorelin | Sermorelin | |
|---|---|---|
| What people use it for | A growth hormone secretagogue, usually taken with CJC-1295 for body composition and recovery. | Stimulating growth hormone release; offered by "anti-aging" and hormone clinics. |
| Approved as a medicine | No | Previously approved for pediatric growth hormone deficiency; the brand is no longer marketed in the US |
| What the evidence says | Phase 1 pharmacology in volunteers and one phase 2 trial in post-surgical ileus that did not meet its primary endpoint. Nothing on muscle, fat or anti-aging. | Once approved, now sold mainly through compounding. Evidence for adult anti-aging use is limited. |
| In tested sport | Prohibited | Prohibited |
Common questions
Which is better, Ipamorelin or Sermorelin?
No study compares them head to head for most uses, so this page compares how much evidence exists, not which works better. Sermorelin has the stronger evidence: FDA-approved, compared with human trials for Ipamorelin.
Is Ipamorelin or Sermorelin approved?
Ipamorelin: not an approved medicine. Sermorelin: Previously approved for pediatric growth hormone deficiency; the brand is no longer marketed in the US.
Can you take Ipamorelin and Sermorelin together?
We found no controlled studies testing Ipamorelin and Sermorelin together, so the effects and safety of combining them are unknown. Talk to a clinician.
Keep exploring
Educational only, not medical advice. "What people use it for" describes common claims, not recommendations.